1 keywords

CATH Domain 6cycB00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt O00408
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

UniProtKB Entries (1)

O00408
PDE2A_HUMAN
Homo sapiens
CGMP-dependent 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 6CYC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor.
Stachel, S.J., Berger, R., Nomland, A.B., Ginnetti, A.T., Paone, D.V., Wang, D., Puri, V., Lange, H., Drott, J., Lu, J., Marcus, J., Dwyer, M.P., Suon, S., Uslaner, J.M., Smith, S.M.
ACS Med Chem Lett