1 keywords

CATH Domain 6cupB01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.870 Son of sevenless (SoS) protein; Chain S, domain 1
Homologous Superfamily 1.20.870.10 Son of sevenless (SoS) protein Chain: S domain 1

Domain Context

CATH Clusters

Superfamily Son of sevenless (SoS) protein Chain: S domain 1
Functional Family son of sevenless homolog 1 isoform X1

Enzyme Information

UniProtKB Entries (1)

Q07889
SOS1_HUMAN
Homo sapiens
Son of sevenless homolog 1

PDB Structure

PDB 6CUP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
Abbott, J.R., Patel, P.A., Howes, J.E., Akan, D.T., Kennedy, J.P., Burns, M.C., Browning, C.F., Sun, Q., Rossanese, O.W., Phan, J., Waterson, A.G., Fesik, S.W.
ACS Med Chem Lett