CATH Classification

CATH Clusters

Superfamily Laminin
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

Q05769
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2

PDB Structure

PDB 6COX
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents.
Kurumbail, R.G., Stevens, A.M., Gierse, J.K., McDonald, J.J., Stegeman, R.A., Pak, J.Y., Gildehaus, D., Miyashiro, J.M., Penning, T.D., Seibert, K., Isakson, P.C., Stallings, W.C.
Nature