CATH Domain 6ca4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.10	Deoxyribonuclease I; Chain A
	3.60.10.10	Endonuclease/exonuclease/phosphatase

Domain Context

CATH Clusters

Superfamily	Endonuclease/exonuclease/phosphatase
Functional Family	Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-

Phosphoric diester hydrolases.

based on mapping to UniProt Q5XJA0

UniProtKB Entries (1)

TYDP2_DANRE

Danio rerio

Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB	6CA4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2). Ribeiro, C.J.A., Kankanala, J., Shi, K., Kurahashi, K., Kiselev, E., Ravji, A., Pommier, Y., Aihara, H., Wang, Z. Eur J Pharm Sci