CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1270.10
Functional Family

Enzyme Information

3.6.4.10
Non-chaperonin molecular chaperone ATPase.
based on mapping to UniProt P11021
ATP + H(2)O = ADP + phosphate.
-!- This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. -!- They comprise a number of heat-shock-cognate proteins. -!- They are also active in clathrin uncoating and in the oligomerization of actin.

UniProtKB Entries (1)

P11021
BIP_HUMAN
Homo sapiens
Endoplasmic reticulum chaperone BiP

PDB Structure

PDB 6ASY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.
Yang, J., Zong, Y., Su, J., Li, H., Zhu, H., Columbus, L., Zhou, L., Liu, Q.
Nat Commun