CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P00327
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P00327
ADH1E_HORSE
Equus caballus
Alcohol dehydrogenase E chain

PDB Structure

PDB 6ADH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 A resolution.
Eklund, H., Samma, J.P., Wallen, L., Branden, C.I., Akeson, A., Jones, T.A.
J.Mol.Biol.