CATH Domain 6a6aA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1380	Muramoyl-pentapeptide Carboxypeptidase; domain 2
	3.30.1380.10

Domain Context

CATH Clusters

Superfamily	3.30.1380.10
Functional Family

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt Q47746

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

Q47746

VANY_ENTFA

Enterococcus faecalis V583

D-alanyl-D-alanine carboxypeptidase

PDB Structure

PDB	6A6A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for the substrate recognition of peptidoglycan pentapeptides by Enterococcus faecalis VanYB. Kim, H.S., Hahn, H., Kim, J., Jang, D.M., Lee, J.Y., Back, J.M., Im, H.N., Kim, H., Han, B.W., Suh, S.W. Int. J. Biol. Macromol.