CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, insert domain
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P9WGZ1
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P9WGH9
SIGH_MYCTU
Mycobacterium tuberculosis H37Rv
ECF RNA polymerase sigma factor SigH

PDB Structure

PDB 5ZX2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for transcription initiation by bacterial ECF sigma factors.
Li, L., Fang, C., Zhuang, N., Wang, T., Zhang, Y.
Nat Commun