CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.12 | Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 |
|
1.10.12.10 | Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 |
| Functional Family | Probable enoyl-CoA hydratase, mitochondrial |
Enzyme Information
| 4.2.1.150 |
Short-chain-enoyl-CoA hydratase.
based on mapping to UniProt P52046
A short-chain (3S)-3-hydroxyacyl-CoA = a short-chain trans-2-enoyl-CoA + H(2)O.
-!- The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. -!- It is specific for short, C(4)-C(6), chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. -!- Cf. EC 4.2.1.17 and EC 4.2.1.74.
|
UniProtKB Entries (1)
| P52046 |
CRT_CLOAB
Clostridium acetobutylicum ATCC 824
Short-chain-enoyl-CoA hydratase
|
PDB Structure
| PDB | 5Z7R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into substrate specificity of crotonase from the n-butanol producing bacterium Clostridium acetobutylicum.
Biochem. Biophys. Res. Commun.
|