CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family Metallo-beta-lactamase NDM-1

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt E5KIY2
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

E5KIY2
E5KIY2_ECOLX
Escherichia coli
Beta-lactamase

PDB Structure

PDB 5YPI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.
Feng, H., Liu, X., Wang, S., Fleming, J., Wang, D.C., Liu, W.
Nat Commun