1 keywords

CATH Domain 5yljF01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.11480  

Domain Context

CATH Clusters

Superfamily 3.40.50.11480
Functional Family tubulin--tyrosine ligase

Enzyme Information

UniProtKB Entries (3)

P63043
STMN4_RAT
Rattus norvegicus
Stathmin-4
E1BQ43
E1BQ43_CHICK
Gallus gallus
Uncharacterized protein
P02554
TBB_PIG
Sus scrofa
Tubulin beta chain

PDB Structure

PDB 5YLJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Yang, J.H., Yan, W., Yu, Y.M., Wang, Y.X., Yang, T., Xue, L.L., Yuan, X., Long, C.F., Liu, Z.W., Chen, X.X., Hu, M.S., Zheng, L., Qiu, Q., Pei, H.Y., Li, D., Wang, F., Bai, P., Wen, J.L., Ye, H.Y., Chen, L.J.
J. Biol. Chem.