1 keywords

CATH Domain 5yl2B02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1330 60s Ribosomal Protein L30; Chain: A;
Homologous Superfamily 3.30.1330.20 Tubulin/FtsZ, C-terminal domain

Domain Context

CATH Clusters

Superfamily Tubulin/FtsZ, C-terminal domain
Functional Family Tubulin beta chain

Enzyme Information

UniProtKB Entries (3)

P63043
STMN4_RAT
Rattus norvegicus
Stathmin-4
E1BQ43
E1BQ43_CHICK
Gallus gallus
Uncharacterized protein
P02554
TBB_PIG
Sus scrofa
Tubulin beta chain

PDB Structure

PDB 5YL2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
Jianhong, Y., Wei, Y., Yamei, Y., Yuxi, W., Tao, Y., Linlin, X., Xue, Y., Caofeng, L., Zuowei, L., Xiaoxin, C., Mengshi, H., Li, Z., Qiang, Q., Heying, P., Dan, L., Fang, W., Peng, B., Jiaolin, W., Haoyu, Y., Lijuan, C.
J. Biol. Chem.