CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1410 | Poly(a)-polymerase, middle domain |
|
1.10.1410.40 |
Domain Context
CATH Clusters
| Superfamily | 1.10.1410.40 |
| Functional Family | Cyclic GMP-AMP synthase |
Enzyme Information
| 2.7.7.86 |
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8C6L5
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
|
UniProtKB Entries (1)
| Q8C6L5 |
CGAS_MOUSE
Mus musculus
Cyclic GMP-AMP synthase
|
PDB Structure
| PDB | 5XZB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun
|