1 keywords

CATH Domain 5xafC01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1440 Tubulin/FtsZ, GTPase domain

Domain Context

CATH Clusters

Superfamily Tubulin/FtsZ, GTPase domain
Functional Family Tubulin alpha chain

Enzyme Information

UniProtKB Entries (3)

E1BQ43
E1BQ43_CHICK
Gallus gallus
Uncharacterized protein
P63043
STMN4_RAT
Rattus norvegicus
Stathmin-4
Q6B856
TBB2B_BOVIN
Bos taurus
Tubulin beta-2B chain

PDB Structure

PDB 5XAF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Zhou, P., Liang, Y., Zhang, H., Jiang, H., Feng, K., Xu, P., Wang, J., Wang, X., Ding, K., Luo, C., Liu, M., Wang, Y.
Eur J Med Chem