CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Possible thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P04818
TYSY_HUMAN
Homo sapiens
Thymidylate synthase

PDB Structure

PDB 5X67
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
Chen, D., Jansson, A., Sim, D., Larsson, A., Nordlund, P.
J. Biol. Chem.