CATH Domain 5x3sA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1120	Arylsulfatase, C-terminal domain
	3.30.1120.30	POLO box domain

Domain Context

CATH Clusters

Superfamily	POLO box domain
Functional Family	Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21

Polo kinase.

based on mapping to UniProt Q07832

ATP + a protein = ADP + a phosphoprotein.

-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

Q07832	PLK1_MOUSE Mus musculus Serine/threonine-protein kinase PLK1
Q14511	CASL_HUMAN Homo sapiens Enhancer of filamentation 1

PDB Structure

PDB	5X3S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. Lee, K.H., Hwang, J.A., Kim, S.O., Kim, J.H., Shin, S.C., Kim, E.E., Lee, K.S., Rhee, K., Jeon, B.H., Bang, J.K., Cha-Molstad, H., Soung, N.K., Jang, J.H., Ko, S.K., Lee, H.G., Ahn, J.S., Kwon, Y.T., Kim, B.Y. J. Biol. Chem.