CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Putative map kinase-interacting serine/threonine-protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9BUB5
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9BUB5
MKNK1_HUMAN
Homo sapiens
MAP kinase-interacting serine/threonine-protein kinase 1

PDB Structure

PDB 5WVD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Matsui, Y., Yasumatsu, I., Yoshida, K.I., Iimura, S., Ikeno, Y., Nawano, T., Fukano, H., Ubukata, O., Hanzawa, H., Tanzawa, F., Isoyama, T.
Acta Crystallogr F Struct Biol Commun