CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.330 | RRM (RNA recognition motif) domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.330 |
| Functional Family | speckle targeted PIP5K1A-regulated poly(A) polymerase |
Enzyme Information
| 2.7.7.19 |
Polynucleotide adenylyltransferase.
based on mapping to UniProt Q9H6E5
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.
|
| 2.7.7.52 |
RNA uridylyltransferase.
based on mapping to UniProt Q9H6E5
UTP + RNA(n) = diphosphate + RNA(n+1).
-!- Requires an oligoribonucleotide or polyribonucleotide with a free terminal 3'-OH as a primer.
|
UniProtKB Entries (1)
| Q9H6E5 |
STPAP_HUMAN
Homo sapiens
Speckle targeted PIP5K1A-regulated poly(A) polymerase
|
PDB Structure
| PDB | 5WU6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structures of U6 snRNA-specific terminal uridylyltransferase
Nat Commun
|