CATH Classification

Domain Context

CATH Clusters

Superfamily Endonuclease/exonuclease/phosphatase
Functional Family

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P27695
4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt P27695
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

P27695
APEX1_HUMAN
Homo sapiens
DNA-(apurinic or apyrimidinic site) lyase

PDB Structure

PDB 5WN1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Whitaker, A.M., Flynn, T.S., Freudenthal, B.D.
Nat Commun