CATH Domain 5wigB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.15	Metallo-beta-lactamase; Chain A
	3.60.15.10	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Context

CATH Clusters

Superfamily	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt C7C422

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

C7C422

BLAN1_KLEPN

Klebsiella pneumoniae

Metallo-beta-lactamase type 2

PDB Structure

PDB	5WIG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Clinical Variants of New Delhi Metallo-beta-Lactamase Are Evolving To Overcome Zinc Scarcity. Stewart, A.C., Bethel, C.R., VanPelt, J., Bergstrom, A., Cheng, Z., Miller, C.G., Williams, C., Poth, R., Morris, M., Lahey, O., Nix, J.C., Tierney, D.L., Page, R.C., Crowder, M.W., Bonomo, R.A., Fast, W. Acs Infect Dis.