CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family Catalase-peroxidase

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt Q8X182
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

Q8X182
KATG_NEUCR
Neurospora crassa OR74A
Catalase-peroxidase

PDB Structure

PDB 5WHS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure, kinetics, molecular and redox properties of a cytosolic and developmentally regulated fungal catalase-peroxidase.
Vega-Garcia, V., Diaz-Vilchis, A., Saucedo-Vazquez, J.P., Solano-Peralta, A., Rudino-Pinera, E., Hansberg, W.
Arch. Biochem. Biophys.