CATH Classification

Domain Context

CATH Clusters

Superfamily Ankyrin repeat-containing domain
Functional Family Palmitoyltransferase

Enzyme Information

2.3.1.225
Protein S-acyltransferase.
based on mapping to UniProt Q8IUH5
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
-!- The enzyme catalyzes the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity. -!- Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.

UniProtKB Entries (1)

P60880
SNP25_HUMAN
Homo sapiens
Synaptosomal-associated protein 25

PDB Structure

PDB 5W7J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.
Verardi, R., Kim, J.S., Ghirlando, R., Banerjee, A.
Structure