CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P03472
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P03472
NRAM_I75A5
Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
Neuraminidase

PDB Structure

PDB 5W26
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.
McKimm-Breschkin, J.L., Barrett, S., Pilling, P.A., Hader, S., Watts, A.G., Streltsov, V.A.
J. Med. Chem.