CATH Domain 5v4lB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.200	Fumarase C; Chain A, domain 2
	1.20.200.10	Fumarase/aspartase (Central domain)

Domain Context

CATH Clusters

Superfamily	Fumarase/aspartase (Central domain)
Functional Family

Enzyme Information

UniProtKB Entries (1)

J9VSX1_CRYNH

Cryptococcus neoformans var. grubii H99

Adenylosuccinate lyase

PDB Structure

PDB	5V4L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Chitty, J.L., Blake, K.L., Blundell, R.D., Koh, Y.Q.A.E., Thompson, M., Robertson, A.A.B., Butler, M.S., Cooper, M.A., Kappler, U., Williams, S.J., Kobe, B., Fraser, J.A. J. Biol. Chem.