CATH Domain 5v4lB01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.275	Fumarase C; Chain B, domain 1
	1.10.275.10	Fumarase/aspartase (N-terminal domain)

Domain Context

CATH Clusters

Superfamily	Fumarase/aspartase (N-terminal domain)
Functional Family

Enzyme Information

UniProtKB Entries (1)

J9VSX1_CRYNH

Cryptococcus neoformans var. grubii H99

Adenylosuccinate lyase

PDB Structure

PDB	5V4L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design. Chitty, J.L., Blake, K.L., Blundell, R.D., Koh, Y.Q.A.E., Thompson, M., Robertson, A.A.B., Butler, M.S., Cooper, M.A., Kappler, U., Williams, S.J., Kobe, B., Fraser, J.A. J. Biol. Chem.