CATH Classification

Domain Context

CATH Clusters

Superfamily Citrate Synthase, domain 1
Functional Family Citrate synthase

Enzyme Information

2.3.3.1
Citrate (Si)-synthase.
based on mapping to UniProt O75390
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
-!- The stereospecificity of this enzyme is opposite to that of EC 2.3.3.3, which is found in some anaerobes. -!- Citrate synthase for which the stereospecificity with respect to C(2) of oxaloacetate has not been established are included in EC 2.3.3.16. -!- Formerly EC 4.1.3.7.

UniProtKB Entries (1)

O75390
CISY_HUMAN
Homo sapiens
Citrate synthase, mitochondrial

PDB Structure

PDB 5UZR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and functional characterization of 2-methylcitrate synthase (mcsA) from Aspergillus fumigatus and citrate synthase (hCS) from Homo sapiens.
Schlachter, C., Chruszcz, M.
To Be Published