CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.437 | Apoptosis Regulator Bcl-x |
|
1.10.437.10 | Blc2-like |
Domain Context
CATH Clusters
| Superfamily | Blc2-like |
| Functional Family | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Enzyme Information
UniProtKB Entries (1)
| Q07820 |
MCL1_HUMAN
Homo sapiens
Induced myeloid leukemia cell differentiation protein Mcl-1
|
PDB Structure
| PDB | 5UUM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife
|