CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Bromodomain-containing protein 2

Enzyme Information

UniProtKB Entries (1)

O60885
BRD4_HUMAN
Homo sapiens
Bromodomain-containing protein 4

PDB Structure

PDB 5UOO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
Zhao, Y., Bai, L., Liu, L., McEachern, D., Stuckey, J.A., Meagher, J.L., Yang, C.Y., Ran, X., Zhou, B., Hu, Y., Li, X., Wen, B., Zhao, T., Li, S., Sun, D., Wang, S.
J. Med. Chem.