CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Rho-associated protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O75116
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O75116
ROCK2_HUMAN
Homo sapiens
Rho-associated protein kinase 2

PDB Structure

PDB 5U7R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Kurasawa, O., Oguro, Y., Miyazaki, T., Homma, M., Mori, K., Iwai, K., Hara, H., Skene, R., Hoffman, I., Ohashi, A., Yoshida, S., Ishikawa, T., Cho, N.
Bioorg. Med. Chem.