CATH Domain 5txfA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Phosphatidylcholine-sterol acyltransferase

Enzyme Information

2.3.1.43

Phosphatidylcholine--sterol O-acyltransferase.

based on mapping to UniProt P04180

Phosphatidylcholine + a sterol = 1-acylglycerophosphocholine + a sterol ester.

-!- Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors. -!- The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.

UniProtKB Entries (1)

P04180

LCAT_HUMAN

Homo sapiens

Phosphatidylcholine-sterol acyltransferase

PDB Structure

PDB	5TXF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I. Manthei, K.A., Ahn, J., Glukhova, A., Yuan, W., Larkin, C., Manett, T.D., Chang, L., Shayman, J.A., Axley, M.J., Schwendeman, A., Tesmer, J.J.G. J. Biol. Chem.