CATH Domain 5tx4A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.60	CD59
	2.10.60.10	CD59

Domain Context

CATH Clusters

Superfamily	CD59
Functional Family	TGF-beta receptor type-2

Enzyme Information

2.7.11.30

Receptor protein serine/threonine kinase.

based on mapping to UniProt P37173

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P61812

TGFB2_HUMAN

Homo sapiens

Transforming growth factor beta-2 proprotein

PDB Structure

PDB	5TX4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. Kim, S.K., Barron, L., Hinck, C.S., Petrunak, E.M., Cano, K.E., Thangirala, A., Iskra, B., Brothers, M., Vonberg, M., Leal, B., Richter, B., Kodali, R., Taylor, A.B., Du, S., Barnes, C.O., Sulea, T., Calero, G., Hart, P.J., Hart, M.J., Demeler, B., Hinck, A.P. J. Biol. Chem.