CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.650 | Cupin |
Domain Context
CATH Clusters
| Superfamily | Cupin |
| Functional Family | Lysine-specific demethylase 4A |
Enzyme Information
| 1.14.11.- |
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O75164
|
UniProtKB Entries (1)
| O75164 |
KDM4A_HUMAN
Homo sapiens
Lysine-specific demethylase 4A
|
PDB Structure
| PDB | 5TVS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.)
|