CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Histone-lysine N-methyltransferase

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9NQR1
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q9NQR1

UniProtKB Entries (1)

Q9NQR1
KMT5A_HUMAN
Homo sapiens
N-lysine methyltransferase KMT5A

PDB Structure

PDB 5TH7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
Butler, K.V., Ma, A., Yu, W., Li, F., Tempel, W., Babault, N., Pittella-Silva, F., Shao, J., Wang, J., Luo, M., Vedadi, M., Brown, P.J., Arrowsmith, C.H., Jin, J.
J. Med. Chem.