1 keywords

CATH Domain 5t3aA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.420 Nucleotidyltransferase; domain 5
Homologous Superfamily 3.30.420.10 Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P35956
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt P35956
3.6.1.23
dUTP diphosphatase.
based on mapping to UniProt P35956
dUTP + H(2)O = dUMP + diphosphate.
3.1.13.2
Exoribonuclease H.
based on mapping to UniProt P35956
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
-!- This is a secondary reaction to the RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end performed by EC 3.1.26.13.
2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt P35956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P35956
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P35956
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P35956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P35956
POL_VILVK
Visna/maedi virus EV1 KV1772
Gag-Pol polyprotein

PDB Structure

PDB 5T3A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A supramolecular assembly mediates lentiviral DNA integration.
Ballandras-Colas, A., Maskell, D.P., Serrao, E., Locke, J., Swuec, P., Jonsson, S.R., Kotecha, A., Cook, N.J., Pye, V.E., Taylor, I.A., Andresdottir, V., Engelman, A.N., Costa, A., Cherepanov, P.
Science