CATH Domain 5t0lB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

2.1.1.45	Thymidylate synthase. based on mapping to UniProt Q07422 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
1.5.1.3	Dihydrofolate reductase. based on mapping to UniProt Q07422 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH. -!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

DRTS_TOXGO

Toxoplasma gondii

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	5T0L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. Welsch, M.E., Zhou, J., Gao, Y., Yan, Y., Porter, G., Agnihotri, G., Li, Y., Lu, H., Chen, Z., Thomas, S.B. ACS Med Chem Lett