CATH Classification

Domain Context

CATH Clusters

Superfamily Peroxidase, domain 2
Functional Family Catalase-peroxidase

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt Q3JNW6
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

Q3JNW6
KATG_BURP1
Burkholderia pseudomallei 1710b
Catalase-peroxidase

PDB Structure

PDB 5SYV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Catalase Activity of Catalase-Peroxidases Is Modulated by Changes in the pKa of the Distal Histidine.
Machuqueiro, M., Victor, B., Switala, J., Villanueva, J., Rovira, C., Fita, I., Loewen, P.C.
Biochemistry