CATH Domain 5pgyA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P28845

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_HUMAN

Homo sapiens

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	5PGY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. Ye, X.Y., Chen, S.Y., Wu, S., Yoon, D.S., Wang, H., Hong, Z., O'Connor, S.P., Li, J., Li, J.J., Kennedy, L.J., Walker, S.J., Nayeem, A., Sheriff, S., Camac, D.M., Ramamurthy, V., Morin, P.E., Zebo, R., Taylor, J.R., Morgan, N.N., Ponticiello, R.P., Harrity, T., Apedo, A., Golla, R., Seethala, R., Wang, M., Harper, T.W., Sleczka, B.G., He, B., Kirby, M., Leahy, D.K., Li, J., Hanson, R.L., Guo, Z., Li, Y.X., DiMarco, J.D., Scaringe, R., Maxwell, B., Moulin, F., Barrish, J.C., Gordon, D.A., Robl, J.A. J. Med. Chem.