CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-oxoacyl-[acyl-carrier-protein] reductase FabG1

Enzyme Information

1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt P71534
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
-!- Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.

UniProtKB Entries (1)

P71534
FABG_MYCS2
Mycolicibacterium smegmatis MC2 155
3-oxoacyl-[acyl-carrier-protein] reductase FabG

PDB Structure

PDB 5OVK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis beta-ketoacyl-acyl carrier protein reductase MabA.
Kussau, T., Flipo, M., Van Wyk, N., Viljoen, A., Olieric, V., Kremer, L., Blaise, M.
Acta Crystallogr D Struct Biol