CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 5ORT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
McIntyre, P.J., Collins, P.M., Vrzal, L., Birchall, K., Arnold, L.H., Mpamhanga, C., Coombs, P.J., Burgess, S.G., Richards, M.W., Winter, A., Veverka, V., Delft, F.V., Merritt, A., Bayliss, R.
ACS Chem. Biol.