CATH Classification

Domain Context

CATH Clusters

Superfamily von Hippel-Lindau disease tumour suppressor, alpha domain
Functional Family von Hippel-Lindau disease tumor suppressor

Enzyme Information

UniProtKB Entries (1)

Q15370
ELOB_HUMAN
Homo sapiens
Elongin-B

PDB Structure

PDB 5NVZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.