CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 5NEV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
Coxon, C.R., Anscombe, E., Harnor, S.J., Martin, M.P., Carbain, B., Golding, B.T., Hardcastle, I.R., Harlow, L.K., Korolchuk, S., Matheson, C.J., Newell, D.R., Noble, M.E., Sivaprakasam, M., Tudhope, S.J., Turner, D.M., Wang, L.Z., Wedge, S.R., Wong, C., Griffin, R.J., Endicott, J.A., Cano, C.
J. Med. Chem.