1 keywords

CATH Domain 5mf6A01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.1220 TPP-binding domain

Domain Context

CATH Clusters

Superfamily TPP-binding domain
Functional Family NAD-dependent protein deacetylase sirtuin-6

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q8N6T7

UniProtKB Entries (1)

Q8N6T7
SIR6_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-6

PDB Structure

PDB 5MF6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.
You, W., Rotili, D., Li, T.M., Kambach, C., Meleshin, M., Schutkowski, M., Chua, K.F., Mai, A., Steegborn, C.
Angew. Chem. Int. Ed. Engl.