CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.15
Cathepsin L.
based on mapping to UniProt P07711
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07711
CATL1_HUMAN
Homo sapiens
Cathepsin L1

PDB Structure

PDB 5MAE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
Giroud, M., Ivkovic, J., Martignoni, M., Fleuti, M., Trapp, N., Haap, W., Kuglstatter, A., Benz, J., Kuhn, B., Schirmeister, T., Diederich, F.
ChemMedChem