CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain
Functional Family Pyruvate dehydrogenase kinase Pkp1

Enzyme Information
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q15119
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

PDB Structure

External Links
Primary Citation
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
Brough, P.A., Baker, L., Bedford, S., Brown, K., Chavda, S., Chell, V., D'Alessandro, J., Davies, N.G., Davis, B., Le Strat, L., Macias, A.T., Maddox, D., Mahon, P.C., Massey, A.J., Matassova, N., McKenna, S., Meissner, J.W., Moore, J.D., Murray, J.B., Northfield, C.J., Parry, C., Parsons, R., Roughley, S.D., Shaw, T., Simmonite, H., Stokes, S., Surgenor, A., Stefaniak, E., Robertson, A., Wang, Y., Webb, P., Whitehead, N., Wood, M.
J. Med. Chem.