CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family 3-phosphoinositide-dependent protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O15530
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O15530
PDPK1_HUMAN
Homo sapiens
3-phosphoinositide-dependent protein kinase 1

PDB Structure

PDB 5LVL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Schulze, J.O., Saladino, G., Busschots, K., Neimanis, S., Su, E., Odadzic, D., Zeuzem, S., Hindie, V., Herbrand, A.K., Lisa, M.N., Alzari, P.M., Gervasio, F.L., Biondi, R.M.
Cell Chem Biol