CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.1370 | Neurolysin; domain 3 |
|
1.10.1370.10 | Neurolysin, domain 3 |
Domain Context
CATH Clusters
| Superfamily | Neurolysin, domain 3 |
| Functional Family | Thimet oligopeptidase 1 |
Enzyme Information
| 3.4.24.16 |
Neurolysin.
based on mapping to UniProt Q9BYT8
Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.
-!- No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. -!- Belongs to peptidase family M3.
|
UniProtKB Entries (1)
| Q9BYT8 |
NEUL_HUMAN
Homo sapiens
Neurolysin, mitochondrial
|
PDB Structure
| PDB | 5LUZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
J. Mol. Biol.
|