CATH Domain 5lsuB00

Superfamily	SET domain
Functional Family

2.1.1.43

Histone-lysine N-methyltransferase.

based on mapping to UniProt O96028

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

NSD2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase NSD2

PDB	5LSU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives. Tisi, D., Chiarparin, E., Tamanini, E., Pathuri, P., Coyle, J.E., Hold, A., Holding, F.P., Amin, N., Martin, A.C., Rich, S.J., Berdini, V., Yon, J., Acklam, P., Burke, R., Drouin, L., Harmer, J.E., Jeganathan, F., van Montfort, R.L., Newbatt, Y., Tortorici, M., Westlake, M., Wood, A., Hoelder, S., Heightman, T.D. ACS Chem. Biol.