CATH Classification

Domain Context

CATH Clusters

Superfamily Extracellular Endonuclease, subunit A
Functional Family Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Enzyme Information

3.1.4.39
Alkylglycerophosphoethanolamine phosphodiesterase.
based on mapping to UniProt Q64610
1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine.
-!- Also acts on acyl and choline analogs.

UniProtKB Entries (1)

Q64610
ENPP2_RAT
Rattus norvegicus
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

PDB Structure

PDB 5LQQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.
Miller, L.M., Keune, W.J., Castagna, D., Young, L.C., Duffy, E.L., Potjewyd, F., Salgado-Polo, F., Engel Garcia, P., Semaan, D., Pritchard, J.M., Perrakis, A., Macdonald, S.J., Jamieson, C., Watson, A.J.
J. Med. Chem.