CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt P22734
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

P22734
COMT_RAT
Rattus norvegicus
Catechol O-methyltransferase

PDB Structure

PDB 5LQN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of COMT in complex with 2-[(3-chlorophenoxy)methyl]-4-methyl-5-(1H-pyrazol-5-yl)-1,3-thiazole
Lerner, C., Rudolph, M.G.
To be published