CATH Classification

Domain Context

CATH Clusters

Superfamily NADH:ubiquinone/plastoquinone oxidoreductase, chain 3
Functional Family NADH-quinone oxidoreductase subunit A

Enzyme Information

7.1.1.2
NADH:ubiquinone reductase (H(+)-translocating).
based on mapping to UniProt O78753
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
-!- The complex is present in mitochondria and aerobic bacteria. -!- Breakdown of the complex can release EC 1.6.99.3. -!- In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH. -!- Formerly EC 1.6.5.3.

UniProtKB Entries (2)

W5NRY1
W5NRY1_SHEEP
Ovis aries
Uncharacterized protein
P23934
NDUS6_BOVIN
Bos taurus
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

PDB Structure

PDB 5LNK
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Atomic structure of the entire mammalian mitochondrial complex I.
Fiedorczuk, K., Letts, J.A., Degliesposti, G., Kaszuba, K., Skehel, M., Sazanov, L.A.
Nature